killer cells are cells of the innate immune system that kills tumor cells
without MHC restriction (Waldhauer and Steinle, 2008). NK cell dysfunction
associated with the development of human breast cancer (Mamessier et al.,
2011). One of the most important functions of natural killer cells are immune
our monitoring body. Some laboratory studies have demonstrated in mammalian
cells, including human cells, and in vivo in mice and rats that natural killer
cells to recognize cancer cells as targets. They control the tumor and
metastasis in vivo growth of the publication.
Tumor immuno-surveillance role of NK
cells has also been implicated in controlling the growth of B cell lymphomas
that spontaneously arise in mice lackingboth perforin and b2-microglobulin.
(Street, et al.,2004). Based on the epidemiologic survey of 11-year follow-up,
there is a link between low NK cell activity in peripheral blood and the
increase of cancer risk in adults. (Imai et. al., 2000).
Advanced breast cancer patients showed
a defect in antitumor immunity, such as a change of DC maturation (Treilleux et
al., 2004) and an increase in Treg infiltrates (Gobert et al., 2009). big drop
maturation of peripheral blood NK cells and cytotoxic function have also been
reported in Metastatic Breast Cancer (Caras et al., 2004).Some gene expression
profile studies have shown that better results
with strong cytotoxic infiltrate containing NK cells (Alexe et al, 2007 ;
Bertucci et al, 2006 ; Finak et al, 2008; Sabatier et al., 2011). These data
indicate that the development of breast cancer associated with antitumor immune
efficiency and in particular NK cells. However, the exact relationship between
NK cells and the development of breast cancer in humans has not been
studied,According Vivier et al. (2008),
NK cells are innate immune cells that are specialized in the detection and
cleaning of modified-self, for example, cancer cells.
Inflammation have role in the pathogenesis of breast cancer. The
tumor microenvironment composed of inflammatory infiltration of
immune cells and fibroblasts activated, they can secrete cytokines, chemokines, and growth
factors, as long as the agent of DNA damage (Coussens and
Werb., 2002), Some studies suggest evidence
that chronic inflammation is associated with relapse of breast cancer and
elevated inflammatory biomarkers associated with reduced survival among breast
cancer patients (Cole ,2009; Pierce et
al .,2009). Moreover,
experimental studies clearly show that inflammatory mediators promote the
growth of tumors in animals susceptible strains (Rao et al., 2006).
In addition, inhibition of TNF-? and
NF-B Kappa (NF- KB) transcription factor shown to be protective against cancer
caused by chemical substances from the mammary gland (Connelly et al., 2011).
Moreover, it may cause in vitro activation axis of TNF-? / NF-KB-invasive and
malignant behavior of breast cancer cells (Balkwill, 2009).