Obsessive-Compulsive Disorder (OCD) is a common,
chronic and long-lasting disorder in which a person has uncontrollable,
reoccurring thoughts (obsessions) and behaviours (compulsions)
that he or she feels the urge to repeat over and over1.
Pharmacological and psychological
treatments are the two most widely used treatments approaches2.
Clomipramine was the first agent found to have efficacy in OCD .The drug shares the pharmacological properties of the
tricyclic group of antidepressants from which it is derived 3.The
antidepressant effects of clomipramine are thought to be due to reuptake
inhibition of serotonin and norepinephrine while serotonin reuptake inhibition only is
believed to be responsible for the effectiveness of clomipramine in the
treatment of OCD4.
SSRIs are generally preferred over clomipramine in
treating OCD. The adverse effect profiles of SSRIs are less, so improved
compliance is observed. Available SSRIs include fluoxetine (Prozac),
fluvoxamine (Luvox), paroxetine (Paxil), citalopram (Celexa), escitalopram
(Lexapro), and sertraline (Zoloft)5.
Despite the proven
efficacy of SSRIs and clomipramine in OCD,
many patients show no or just partial symptom improvement to a treatment
with a first-line drug. The combination of the antipsychotics risperidone,
haloperidol, olanzapine, or quetiapine with an SSRI was shown to be more
effective than SSRI monotherapy in such cases and is recommended by the WFSBP World Federation of Societies of
Prescribing a suitable
medication for a particular patient is done on the basis of many factors
including patient’s demographic characteristics, illness profile, side effects
of the medication, co morbidities. So, analysis of prescription patterns
can help in identifying prevalent practices of the use of medications in real
The concept of QOL is often considered a missing
measurement in healthcare. Inquiry into QOL proved to be useful because many
studies in the recent time showed correlations between QOL and distress that
often leads to worsening of symptoms
such as those of OCD. Hence, the aim of the present study was to assess and quantify
QOL in patients suffering from OCD8.
Today, in an age where health care is scrutinized, not
only for the quality of that which we provide but also the satisfaction of
those who receive it. Patient satisfaction along with the health care provided
by doctors is of great medical significance. Thus, it is important to find out weaknesses in systems to aid improvement
through the patient’s eyes9.